Home > Disease > Drugs Targeting DNA Proteins

Drugs Targeting DNA Proteins

By: Ian Murnaghan BSc (hons), MSc - Updated: 8 Sep 2016 | comments*Discuss
 
Dna Discovery Disease Target Drugs

With a seemingly endless array of drugs on the market today, the principles of drug therapy still have not changed much in the simplistic sense that drugs must reach and impact their target to be successful. Many drugs work as inhibitors, where they stop the actions of a specific protein. DNA is a key target for the delivery of drugs because of it interfering with how genes are expressed and how proteins are created. In addition, the replication process for DNA can be affected as well, which is important for cell growth as well as a cell's ability to successfully divide.

How Do Drugs Bind to DNA?

There are actually a few ways that drugs can bind to DNA and one key way is by controlling special enzymes and factors involved in transcription. Here, the drugs target proteins that bind to the DNA. Another way involves molecules that bind to the double helix parts of DNA and interfere with the interactions between DNA and proteins.

One type of target are telomerase inhibitors and this is an area related to cancer treatment. Telomeres are at chromosome ends and they protect the ends from damage and help to make sure DNA replication occurs as intended. In somatic cells, the life span has an 'end date.' A tumour cell, on the other hand, keeps its telomere ends stable, so that the tumour cell can continue to survive. This, of course, presents a predicament for treatment but telomerase inhibitors have addressed this dilemma for researchers. Telomerase inhibitors work to halt the action of an enzyme known as reverse transcriptase telomerase. This particular enzyme is what helps tumour cells keep the telomere ends stable, so stopping its action can direct the tumour cell to begin apoptosis, which is a term that refers to programmed cell death.

New Ways to Attach to DNA

In the last several years, research has also focused on how drugs targeting DNA proteins can actually attach themselves to the DNA. It was around the 1960s that researchers identified three separate classes of drugs that have different mechanisms for attaching to DNA. New studies have now shown a fourth mechanism, which shows enormous promise for drugs used in treatments such as cancer. The researchers are based in the United Kingdom and have created a mechanism for binding in the middle of a multi-way junction found in the DNA. In some diseases, multi-way junctions are created when the DNA double-helix areas fuse together.

The discovery is exciting because it provides a new and successful way to address the challenges in drug binding to targets. While there are still numerous drugs on the market to treat cancer via DNA, they are not nearly as focused as this current mechanism. They also carry many uncomfortable side effects, which means the discovery of an effective way to target DNA without bothersome side effects is important. The resistance that can occur from drugs also means that it is important for researchers to consistently be developing new ways to treat disease. Fortunately, this new discovery addresses such challenges.

Future of Drugs Targeting DNA

Drugs will continue to be developed to target DNA proteins. Their discovery requires thorough animal and human testing to ensure that a specific protein's role in disease is well validated and that the drug acts accordingly to inhibit the protein's action. Our increasing knowledge of DNA and its role in the body can hopefully provide more successful treatments that target disease and help those who suffer from the devastating effects.

You might also like...
Share Your Story, Join the Discussion or Seek Advice..
how can i find out what kind of drug that target DNA synthesis
james - 17-Feb-13 @ 7:35 AM
Share Your Story, Join the Discussion or Seek Advice...
Title:
(never shown)
Firstname:
(never shown)
Surname:
(never shown)
Email:
(never shown)
Nickname:
(shown)
Comment:
Validate:
Enter word:
Topics
Latest Comments
  • bhad bhabie
    Re: DNA Sequencing
    why is this sooo long and its hard to understand what this is talking about.
    19 October 2018
  • Rhonda
    Re: DNA Test after Death
    My grandfather died in 1959 and I was wondering if you could do dna from an old pipe of his.
    17 October 2018
  • Rhonda
    Re: DNA Test after Death
    Can you take dna from an old pipe. My grandfather died in 1959 and we only have an old pipe.
    17 October 2018
  • Shelley1964
    Re: DNA Test after Death
    I am trying to get citizenship for the UK as my father was born there. However my parents were not married at the time of my birth and my…
    15 October 2018
  • Nadeoui Eden
    Re: DNA Test after Death
    I am 73 years old. My birth father died in 1976 and I know where he is buried. I have been very active in family research, but have no…
    13 October 2018
  • Nadeoui Eden
    Re: DNA Test after Death
    I am 72 years old. My birth father never gave us accurate family information. I know where he is buried. Would it be legal or possible for me…
    13 October 2018
  • ugly lil boy
    Re: DNA Sequencing
    exscuse me my name is mariah and i need my answer for i tell on all of yall.
    12 October 2018
  • b vf
    Re: The Properties of DNA
    you better tell me what the 5 chararistics of dna are \
    12 October 2018
  • Enoch Correa
    Re: DNA Test after Death
    My son died on july and i think that the ashes they give me not belong to my son how can i do to find out that the ashes they give me belongs…
    30 September 2018
  • Suzette Brits
    Re: DNA Test after Death
    My sister reasonly found out that my father was not her farther we did a paternity test which confirmed this. We suspect who the real farther…
    26 September 2018